Schizencephaly

Schizencephaly is a development disorder characterized by abnormal rives in the cerebral hemispheres (NINDS publication). Some scientists deem it to be a more or less severe, yet restricted, of the cortical malformations (Volpe, 1995). The pathology of this disorder shows that the cleft may be narrow or closed or wide and open. The cleft is unremarkably located near the precentral or postcentral gyri, they can be unilateral (occurring on only one side) or isobilateral (occurring on both sides). Multiple small convolutions in the misshapen brain, or polymicrogyria, have been noted. Other malformations included or usually noted with this disorder are microcephaly (small brain), gray matter heterotopia (absence of binocular equilibrium in the eyes), dysplasia (abnormal tissue development) and hypoplasia (tissue underdevelopment) (Carson, 1996). It has been deemed a cephalic disorder (by NINDS), congenital neurologic malformation (Icenogle & Kaplan, 1981), or a neuronal migration disorder (Volpe, 1995). All are accurate and fundamentally describe some specific characteristics of the disorder. As in both discussion of a neurologic disorder, the discussion of its onset is polar in defining it.

There is believed to be a resound agenesis of a portion of the germinative zones and thereby the cerebral mol that leaves the seams or clefts in this anatomical abnormality. This injury in the germinative zones is also deemed to affect the migrating neurons-therefore the notion of neuronal migration disorder. Migrational events in the cerebrum dally in the third month of gestation. For a better understanding, a brief discus! sion of ontogenesis-the summons of predetermined events occurring in comme il faut sequence to insure normal development of the CNS-is in order. district ontogenesis of neural tissue is a complex surgical operation that can be divided into three developmental phases: (1) embryogenesis from 0 to 1 month of gestation characterized by induction; (2) cellular...If you want to get a full essay, order it on our website: BestEssayCheap.com

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